Given the changing business environment of small and medium-sized enterprises (SMEs) in developing countries, the need for mechanisms aimed at enhancing technology transfer and at channelling investment has become vital for the improvement of the productivity and competitiveness of SMEs. The Johannesburg Plan of Implementation of the World Summit on Sustainable Development identified technology transfer as one of the major instruments for assisting developing countries to move towards sustainable development. Targeting decision-makers, academics, the financial community, and business associations and networks, this study endorses commitments adopted at the Summit and synthesizes a series of activities undertaken by ESCWA aimed at assessing and strengthening the development of SMEs cluster in Jordan, Lebanon and Morocco.